Broncos vs Colts odds, line, spread: Thursday Night Football picks, NFL predictions from computer model


A Thursday night football game features the Denver Broncos (2-2) hosting the Indianapolis Colts (1-2-1) in a prime-time battle. The Colts will be without star running back Jonathan Taylor, who is out with an ankle injury, while the Broncos will be without young running back Javonte Williams, who is out for the season with a torn anterior cruciate ligament. Last Sunday, the Colts lost to the Tennessee Titans, 24-17. Likewise, Denver fell to the Las Vegas Raiders, 32-23.

Kickoff is scheduled for 8:15 p.m. ET in Denver. Caesars Sportsbook lists Denver as a three-point favorite in the latest Broncos vs. Colts odds. The over/under for total points is 42. Before making any Colts vs. Broncos picks, be sure to check out the NFL predictions and SportsLine projection model betting tips.

The model, which simulates every NFL game 10,000 times, has grown nearly $7,000 for players to $100 on top NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on NFL’s top picks that dates back to the 2017 season.

The model has also ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.

Now the model has set its sights on the Broncos vs. Colts and has just locked in its TNF picks and predictions. You can visit SportsLine now to see the model choices. Here are the NFL odds and betting lines for the Colts vs. Broncos:

  • Gap Broncos vs. Colts: Denver -3
  • Broncos vs. Colts over/under: 42 points
  • Broncos vs. Colts silver line: Indianapolis +143, Denver -170
  • IND: Colts are 5-1 ATS in last six games after back-to-back loss
  • DEN: Broncos are 5-0 ATS in last five home games against record-losing teams on the road
  • Broncos vs. Colts picks: See picks here

Featured Game | Denver Broncos vs. Indianapolis Colts

Why the Broncos can cover

Denver’s defensive line has players who can build pressure and tackle the quarterback. Defensive end Dre’Mont Jones is underrated and plays regularly. Jones is solid against the run with pass-rush moves to get into the backfield. The Ohio State product has 14 total tackles, three TFLs and two sacks. Bradley Chubb is another edge force for the Broncos.

Chubb has long arms and a range of moves to evade blockers. Pro Bowler 2020 explodes offline and is very active. He leads the team in sacks (three) with three tackles for the loss. Cornerback Patrick Surtain II played well in the first quarter of the season. Surtain II boasts elite height, length and instincts with flowing hips. The Alabama product thrives in men’s coverage but is superb in the zone. He recorded 15 tackles with a team-high four pass deflections.

Why the Colts can cover

Indianapolis has a versatile and efficient secondary that plays fast and stays disciplined on the backend. The Colts are 10th in passing yards allowed (207.5). Cornerback Kenny Moore II is a valuable piece in the slot for this team. Moore II excels as an edge blitzer and has natural ball-peddling skills. The 2021 Pro-Bowler is third on the team in total tackles (19) with one pass deflection.

Stephon Gilmore is still a strong, well-rounded corner on the outside. Gilmore has been instinctive throughout his career with the ability to consistently break passes. The five-time Pro-Bowl selection currently has 14 total tackles with two pass deflections. Safety Rodney McLeod is a savvy veteran on the backend who doesn’t make many mistakes while possessing solid closing speed. The UVA product recorded 15 saves, two passing deflections and one interception.

How to Make Broncos vs. Colts Picks

SportsLine’s model leans under the total, calling for a combined 40 points. It also indicates that one side of the gap is cashing in well over 50% of simulations. You can only get the model’s TNF picks from SportsLine.

So who wins the Colts against the Broncos on Thursday Night Football? And which side of the spread cashes well more than 50% of the time? Visit SportsLine now to see which side of the Colts vs. Broncos spread, all from the forward model that’s risen nearly $7,000 on its NFL picks since 2017, and find out.


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